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. 2021 Jun 30;41(26):5734–5746. doi: 10.1523/JNEUROSCI.3210-20.2021

Figure 3.

Figure 3.

Bar does not change energy expenditure and physical activity. A, C, E, G, I, Temporal changes in oxygen consumption (A), carbon dioxide production (C), heat production (E), xy-axis activity (G), and z-axis activity (I) in Veh + Veh, Veh + Lor, Bar + Veh, and Bar + Lor groups. N = 7 mice per group. Data are presented as mean ± SEM. Two-way repeated measures ANOVA, [dot]VO2: time × group (dark phase: F(39,234) = 1.43, p = 0.058; light phase: F(36,216) = 1.23, p = 0.19); [dot]VCO2: time × group (dark phase: F(39,234) = 1.42, p = 0.065; light phase: F(36,216) = 1.24, p = 0.18); heat: time × group (dark phase: F(39,234) = 1.44, p = 0.056; light phase: F(36,216) = 1.24, p = 0.18); heat: time × group (dark phase: F(39,234) = 1.44, p = 0.056; light phase: F(36,216) = 1.24, p = 0.18); xy-axis activity: time × group (dark phase: F(39,234) = 2.26, p < 0.0001; light phase: F(36,216) = 0.967, p = 0.53); z-axis activity: time × group (dark phase: F(39,234) = 2.01, p = 0.0008; light phase: F(36,216) = 0.94, p = 0.58), with post hoc Sidak's multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001. N = 7 mice per group. Data are presented as mean ± SEM. B, D, F, H, J, Average dark and light oxygen consumption (B), carbon dioxide production (D), heat production (F), xy-axis activity (H), and z-axis activity (J) in Veh + Veh, Veh + Lor, Bar + Veh, and Bar + Lor groups. Two-way ANOVA, Lor × Bar: ([dot]VO2: dark phase: F(1,24) = 0.32, p = 0.57; light phase: F(1,24) = 0.58, p = 0.45; [dot]VCO2: dark phase: F(1,24) = 0.71, p = 0.41; light phase: F(1,24) = 0.95, p = 0.34; heat: dark phase: F(1,24) = 0.33, p = 0.57; light phase: F(1,24) = 0.10, p = 0.74; xy-axis activity: dark phase: F(1,24) = 0.93, p = 0.34; light phase: F(1,24) = 0.08, p = 0.78; Y-axis activity: dark phase: F(1,24) = 0.09, p = 0.76; light phase: F(1,24) = 0.10, p = 0.75), with post hoc Sidak's multiple comparisons test. N = 7 mice per group. Data are presented as mean ± SEM with individual data points.