Figure 6.

Nerve injury induced punctate mechanical allodynia in Merkel cell-deficient male mice in the SNI model. A–L, Punctate mechanical sensitivity measured across forces in the ipsilateral sural nerve-innervated hind paw skin at baseline (A,D,G,J) and 28 d (B,E,H,K) after SNI and time course of hind paw sensitivity to 0.02 g (C,F,I,L) von Frey filament in K14^Cre+;Atoh1^fl/fl and Cre-negative Atoh1^fl/fl control male mice. A-C, Cohort 1. D-F, Cohort 2. G-I, Cohort 3. J-L, Cohort 4. Data are mean ± SEM. Two-way ANOVA with p value from overall comparison between genotypes over time or force shown at top and number of mice in parentheses. Results of Bonferroni post hoc correction: *p < 0.05; **p < 0.01; Cre-positive versus Cre-negative.