Figure 8.

Nerve injury induced thermal hyperalgesia in Merkel cell-deficient male and female mice in the SNI model. A–C, Time course of thermal sensitivity after SNI on ipsilateral (A, Cohort 1), ipsilateral (B, Cohort 2), and ipsilateral (C, Cohort 3) sural nerve-innervated hind paw skin of K14^Cre+;Atoh1^fl/fl and Cre-negative Atoh1^fl/fl control male mice. D–F, Time course of thermal sensitivity after SNI on ipsilateral (D, Cohort 1), ipsilateral (E, Cohort 2), and ipsilateral (F, Cohort 3) sural nerve-innervated hind paw skin in K14^Cre+;Atoh1^fl/fl and Cre-negative Atoh1^fl/fl control female mice. Data are mean ± SEM. Two-way ANOVA with p value from overall comparison between genotypes over time shown at top and number of mice in parentheses.