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. 2021 Jun 30;7(27):eabh3805. doi: 10.1126/sciadv.abh3805

Fig. 6. The ensemble structure of membrane-embedded full-length hGHR-GFP.

Fig. 6

(A) Representative ensemble of conformations obtained from the last 1.5 μs of each of the 20 runs of 2-μs hGHR-GFP + POPCpws10 simulations. Color scheme and representations as in Fig. 5C. (B) Examples of the multitude of domain orientations of hGHR-GFP in the membrane. In the first panel, the structures of hGH (PDB 3HHR_A; orange) and of JAK2-FERM-SH2 (PDB 4Z32; red) are shown. Color scheme and representation of hGHR and POPC as in Fig. 5C.