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In vitro uptake of coumarin-6-NP, Bo-coumarin-6-NP, and Bo-loaded-coumarin-6 NP by 16HBE cells. (A) Uptake index of coumarin-6-NP, Bo-coumarin-6-NP, and Bo-loaded-coumarin-6-NP in 16HBE cells; effects of different (B) Bo–PEG–PLGA/PEG–PLGA ratio, (C) NP concentration, (D) incubation time, and (E) temperature on the uptake index of Bo modified NPs by 16HBE cells (compared to un-modified coumarin-6 NP). *p< .05; **p< .01.
