Table 2.

Odds ratio (with 95% confidence interval) in the fully adjusted model (by differences in baseline patient characteristics and severity of the acute heart failure episode) for adverse short-term outcomes for patients who received intravenous furosemide during the prehospital phase (FAST-FURO group) compared with those who did not receive this treatment (CONTROL group)

	In-hospital all-cause mortality OR (95% CI)	30-day all-cause mortality OR (95% CI)	Prolonged hospitalization OR (95% CI)
Primary adjusted analysis	1.080 (0.817–1.427)	1.086 (0.845–1.396)	1.095 (0.915–1.312)
Sensitivity analysis A (including patients not treated with IV furosemide at ED)	1.231 (0.953–1.590)	1.161 (0.978–1.378)	1.161 (1.043–1.225)
Sensitivity analysis B (only hospitalized patients)	0.918 (0.686–1.229)	0.935 (0.716–1.222)	0.981 (0.817–1.179)
Sensitivity analysis C (only patients brought to ED by EMS)	0.937 (0.704–1.246)	1.004 (0.777–1.298)	1.051 (0.871–1.269)
Sensitivity analysis D (only patients with previously known HF)	1.321 (0.950–1.836)	1.246 (0.926–1.677)	1.056 (0.836–1.332)
Sensitivity analysis E (without multiple imputation)	0.920 (0.571–1.482)	0.996 (0.659–1.506)	0.958 (0.723–1.269)
Sensitivity analysis F (patients missed at 30-day follow up considered as deaths, worst case scenario)	—	1.180 (0.934–1.492)	—
Sensitivity analysis G (including only patients with known LVEF)	1.248 (0.866–1.798)	1.172 (0.840–1.634)	1.091 (0.865–1.375)
Sensitivity analysis H (with 599 pairs of patients matched by propensity score)	1.166 (0.775–1.754)	1.217 (0.846–1.752)	1.161 (0.890–1.514)

Reference group for all ORs is CONTROL group.

CI, confidence interval; ED, emergency department; EMS, emergency medical service; LVEF, left ventricular ejection fraction; OR, odds ratio.