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. 2021 Jul 1;131(13):e147066. doi: 10.1172/JCI147066

Figure 3. Vaccine-induced Ab responses in children who experienced DENV3 breakthrough infections.

Figure 3

Vaccine responses were analyzed in baseline seronegative children who received Dengvaxia and subsequently experienced DENV3 (n = 18) breakthrough infections. (A) DENV3 NAb responses after vaccination were measured without depleting any Ab (Control depleted), after removal of all DENV3-binding Abs (Complete Ab depleted with DENV3 antigen), and after removal of CR Ab (CR Ab depleted using a mix of DENV1, DENV2, and DENV4 antigens). (B) DENV4 NAb responses after vaccination were measured without depleting any Ab (Control depleted), after removal of all DENV4-binding Abs (Complete Ab depleted with a mix of DENV1, DENV2, and DENV4 antigens), and after removal of CR Ab (CR Ab depleted using DENV3 antigen). (C) The data were also analyzed to compare the percentages of DENV3 and DENV4 TS NAbs in the children after vaccination. Friedman’s 1-way ANOVA test (A and B) or Wilcoxon’s signed ranks test (C) was used to establish statistical significance.