Figure 4. Dengvaxia-induced Ab responses in children with no preexisting immunity to DENVs.

Dengvaxia recipients irrespective of subsequent outcome during CYD-TDV clinical trials were tested to determine levels of total and TS DENV1 (A), DENV3 (B), and DENV4 (C) NAbs. Wilcoxon’s signed ranks test was used to establish statistical significance. The data were also analyzed to compare the percentages (D) of vaccine-induced DENV1, DENV3, and DENV4 TS NAbs. Kruskal-Wallis test was used to compare Ab responses between serotypes. Supplemental Table 3 displays the DENV antigen combinations used for depletion to measure levels of TS NAbs to each serotype.