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. 2021 Jul 1;131(13):e146077. doi: 10.1172/JCI146077

Figure 2. Box-and-whisker plots of various hemolysis levels by genotype for GWA-significant nonsynonymous variants by ancestry group.

Figure 2

Osmotic hemolysis: (A) Osmotic SPTA1 (rs857725/Lys1693Gln); (B) osmotic HBA2 (chr16: 223678); (C) osmotic HBB (rs334/Gul7Val) (HbS). n = 12,219 for all osmotic analyses. Oxidative hemolysis: (D) Oxidative SEC14L4 (AX-83171224/rs9606739) Arg112Gly; (E) oxidative G6PD (rs1050828) Val68Met is on the X chromosome; therefore, male and female sample members are displayed separately. n = 10,007 for all oxidative analyses. Spontaneous hemolysis: (F) Storage TMC8 (rs7208422) Asn306Ile. Minor allele homozygotes are in shades of red, heterozygotes in green, and reference allele homozygotes in shades of blue. n = 12,219 for all storage analyses. For the box-and-whisker plots, the bounds of the box are the 25th and 75th percentiles, the line in the box is the 50th percentile/median. The whiskers are 1.5 times the interquartile range (25%–75%), and black dots are values outside the whiskers. Ancestry groups: AFR, African Americans; EUR, non-Hispanic Whites; EAS, East Asians; SAS, South Asians; CIH, Caribbean Island Hispanics; MCAH, Mexican/Central American Hispanics; OTH, other.