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. 2021 Jul 1;131(13):e143414. doi: 10.1172/JCI143414

Figure 2. Mice with pancreas-specific loss of Pten and Sav1 spontaneously develop CP.

Figure 2

Pancreatic phenotypes were examined in WT mice, pancreas-specific Pten knockout (PTEN-KO) mice, Sav1-knockout (SAV1-KO) mice, and Pten and Sav1 double knockout (DKO) mice at 6 weeks of age. (A) Macroscopic images of the pancreas. (B) Pancreas weight. (C) Representative images of H&E, Sirius red, and SOX9 staining of pancreatic tissue. (D) Protein levels of AKT, p-AKT, YAP, p-YAP, and ACTB in the pancreata of mice. (E) Cd68, Tnfa, Il1b, Ccl2, Tgfb1, Col1a1, Col1a2, and Ctgf mRNA levels in pancreatic tissue. Blots run in parallel contemporaneously are shown. All data are presented as the means ± SDs of results for 3 mice per group. One-way ANOVA with Tukey’s post hoc test was used to compare differences among 4 groups. †P < 0.05 vs. all groups. Scale bars: 100 μm and 50 μm (insets).