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. 2021 Jul 1;131(13):e143414. doi: 10.1172/JCI143414

Figure 6. CTGF inhibition ameliorates CP by alleviating inflammation, fibrogenesis, and ADM formation in vivo.

Figure 6

Pancreatic phenotypes were examined in vehicle-treated mice (control) and mice with cerulein-induced CP upon treatment with control IgG or FG-3154 (40 mg/kg) twice weekly for 2 weeks. (A) Therapeutic protocol. (B) Macroscopic images of the pancreas. (C) Pancreas weight. (D and E) Representative images of H&E, Sirius red, and SOX9 staining of pancreatic tissue (D) and quantification of the Sirius red–positive area (E, left) and SOX9 staining intensity (E, right). (F) Pten, Sav1, Cd68, Tnfa, Il1b, Ccl2, Tgfb1, Col1a1, and Col1a2 mRNA levels in pancreatic tissue. All data are presented as the means ± SDs of results for 4 mice per group. One-way ANOVA with Tukey’s post hoc test was used to compare differences among 3 or 4 groups. *P < 0.05, **P < 0.005, and †P < 0.05 vs. all groups. Scale bars: 100 μm and 50 μm (insets).