Figure 6. Basophil-specific IL-4/IL-13 depletion alters healing after MI.

(A and B) Percentage of cardiac Ly6C^hi monocytes and Ly6C^lo macrophages (among the percentage of total Lin^–CD11b⁺ cells) 4 days after MI (n = 8–9). Data show the mean ± SD. P values were determined by 2-tailed Student’s t test. (C) Representative flow cytometric plots of cells from infarct tissue 4 days after MI in Baso^WT and Baso^4-13KO mice gated on monocytes/macrophages. (D and E) Echocardiographic evaluation of baseline EF and plasma cTnT levels 24 hours after LAD ligation in Baso^WT and Baso^4-13KO mice. (F) Representative echocardiographic images of mice from the indicated groups on day 1 and day 28 after MI. (G–I) Echocardiographic results for Baso^WT and Baso^4-13KO mice 4 weeks after MI (n = 6–8). Data show the mean ± SD. P values were determined by 2-tailed Student’s t test. (J) Quantification of LV scar thickness based on histological evaluation 4 weeks after MI (n = 6–8). Data show the mean ± SD. P value was determined by 2-tailed Student’s t test. (K) Representative images of histological sections stained with Masson’s trichrome 4 weeks after MI. Scale bars: 500 μm.