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. 2021 Jul 1;131(13):e144201. doi: 10.1172/JCI144201

Figure 3. Passive transfer of hypersensitivity by IgG pooled from multiple patients.

Figure 3

Visual analog pain scores (VAS, A) and pressure-pain thresholds (PPT, B) in 2 pools of FMS patients and healthy control (HC) subjects. Pool 1, n = 8 FMS and n = 12 HC; Pool 2, n = 14 FMS and n = 10 HC. **P < 0.01, ***P < 0.001 by Mann-Whitney U test. Administration of IgG pooled from FMS patients produced mechanical (C) and cold (D) hypersensitivity in mice compared with pooled HC IgG, 4 days after the first injection. Pool 1, n = 6 mice per group; Pool 2, n = 12; line and whiskers indicate mean ± SEM. **P < 0.01, ***P < 0.001 by unpaired, 2-tailed t test. Time course of mechanical (E) and cold (F) hypersensitivity following administration of pooled IgG (Pool 1). *P < 0.05, FM vs. HC IgG; 2-way repeated measure ANOVA with Sidak’s correction. †P < 0.05, ††P < 0.01, compared with day zero; 2-way repeated measure ANOVA followed by Dunnett’s test. Data in E and F are mean ± SEM of 6 mice per group.