Figure 4. IgG-depleted serum is inactive.

IgG from an FMS patient, but not IgG-depleted serum from the same patient or pooled from FMS or HC cohorts, produced mechanical (A) and cold (B) hypersensitivities. **P < 0.01, ***P < 0.01, FM vs. HC IgG; 2-way repeated measure ANOVA followed by Sidak’s correction. Data points are mean ± SEM of 6 mice per group.