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. 2021 Jul 1;131(13):e144201. doi: 10.1172/JCI144201

Figure 5. Passive transfer of FMS IgG decreases locomotor activity.

Figure 5

Visual analog pain scores (VAS, A) and pressure-pain thresholds (PPT, B) reported by FMS patients and healthy control (HC) subjects in Pool 3. Following transfer of HC or FMS IgG to mice, locomotor activity was assessed over a 24-hour period using a Comprehensive Animal Lab Monitoring System. The total number of recorded movements was similar between HC IgG and FMS IgG mice during the day phase (low activity), but FMS IgG–injected mice showed less activity during the night phase (high activity) (C). The night phase was divided into 3 phases: 18:00–22:00 hours (D), 22:00–02:00 hours (E), and 02:00–06:00 hours (F), indicated by the dotted lines. Mice injected with FMS IgG displayed significantly less locomotor activity during the peak activity phase (E) compared with HC IgG–injected mice. Data points are mean ± SEM, FMS n = 14, HC n = 11, n =12 mice per group. *P < 0.05, ***P < 0.001 by Mann-Whitney U test (A and B), 2-way ANOVA followed by Bonferroni’s correction (C), or unpaired t test (D–F).