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. 2021 Jul 1;131(13):e141614. doi: 10.1172/JCI141614

Figure 1. Schematic representation of the recombinant measles virus (MV) oncolytic vaccine platforms.

Figure 1

(A) The Edmonston vaccine strain of the MV backbone was modified to generate the MV-s-NAP, MV-GFP, MV-s-NAP-uPA, and MV-GFP-uPA recombinant strains. Where indicated, the virus was modified to encode secretory NAP protein, GFP reporter, and murine uPA ligand. The N, P, M, F, H, and L in the virus genome diagram correspond to MV proteins: nucleoprotein (N), phosphoprotein (P), matrix (M) protein, fusion (F) protein, hemagglutinin (H), and large (L) protein. (B) Stable expression of murine uPA receptor 1 (uPAR-1) was measured in CT-2A and GL261 syngeneic murine glioblastoma cells in culture after 20 cell passages. (C) Mean fluorescence intensity (MFI) of uPAR expression in CT-2A and GL261 cells. The experiment was repeated twice with similar outcomes. Values represent mean ± SD (n = 3/group). ***P < 0.001 by 2-tailed, unpaired t test.