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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Nature. 2021 Feb 3;591(7851):665–670. doi: 10.1038/s41586-020-03150-2

Extended Data Figure 5 |. Relative Ago1 and Ago2 binding ratio of ActB-sdRNA compared to its precursor.

Extended Data Figure 5 |

a-b, BRCA1 RIP analyses of the sdRNA or its precursor, showing the raw data represented as %input (a) or as the fold change of the signal obtained between the relevant Ab BRCA1 and a beads-only control (b). c, RIP analysis showing the binding ratio (Log2) between ActB-sdRNA and its precursor (quantified by Taqman and strand specific RT-qPCR) after Ago1 or Ago2 IP from HeLa whole cell extracts (WCE).