Figure 1.

Re‐analysis of scRNA‐seq data from Wilk et al. shows no supporting evidence for the hypothesis that ‘developing neutrophils’ transdifferentiate from plasmablasts. (a) Reconstruction of the UMAP embedding from Figure 1c of Wilk et al. (b) Reconstruction of the UMAP embedding from Figure 2a of Schulte‐Schrepping et al. (c) Integrated Wilk et al.’s and Schulte‐Schrepping et al.’s data sets. ‘Developing neutrophil’ embeddings are closer to neutrophils and the myeloid cell compartment, while plasmablasts remain associated with B cells. (d) Integrated Wilk et al.’s and Schulte‐Schrepping et al.’s data sets. ‘Developing neutrophils’ from the Wilk et al. study (c) colocalise with immature neutrophils in this cohort.