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. 2021 Jun 14;44(6):401–407. doi: 10.14348/molcells.2021.0079

Fig. 2. Differentiation of SARS-CoV-2-specific CD8+ T cells during the convalescent period of COVID-19.

Fig. 2

From the early convalescent to the late convalescent phases, the frequency of SARS-CoV-2-specific CD8+ T cells expressing CD38 and PD-1 decreases gradually, whereas the frequency of SARS-CoV-2-specific CD8+ T cells expressing CCR7, CD45RA, and CD127 increases. In particular, among SARS-CoV-2-specific CD8+ T cells, the frequency of CCR7+CD45RA+CD95+ stem cell-like memory T (TSCM) cells that have the capacity for self-renewal and multipotency increases in the late convalescent phase. The generation of TSCM cells is also observed among SARS-CoV-2-specific CD4+ T cells.