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. 2021 Jul;2(7):e407–e416. doi: 10.1016/S2666-7568(21)00117-3

Table 1.

Characteristics of participants by cognitive impairment definition

All participants (n=5687) Participants with cognitive impairment
Definition 1 (n=821) Definition 2 (n=1485) Definition 3 (n=338) Definition 4 (n=837) Definition 5 (n=347) Definition 6 (n=826) Definition 7 (n=354)
Demographics
Age, years 65·7 (5·9) 65·8 (5·9) 67·0 (6·0) 67·2 (6·0) 66·0 (6·0) 67·2 (6·1) 65·8 (6·1) 67·2 (6·1)
Sex
Female 1552 (27·3%) 264 (32·2%) 454 (30·6%) 113 (33·4%) 253 (30·2%) 108 (31·1%) 241 (29·2%) 109 (30·8%)
Male 4135 (72·7%) 557 (67·8%) 1031 (69·4%) 225 (66·6%) 584 (69·8%) 239 (68·9%) 585 (70·8%) 245 (69·2%)
Education
Lower secondary school or less 2374 (41·7%) 487 (59·3%) 649 (43·7%) 191 (56·5%) 347 (41·5%) 150 (43·2%) 400 (48·4%) 171 (48·3%)
Higher secondary school 1556 (27·4%) 190 (23·1%) 394 (26·5%) 85 (25·2%) 222 (26·5%) 96 (27·7%) 205 (24·8%) 86 (24·3%)
University degree or higher 1757 (30·9%) 144 (17·6%) 442 (29·8%) 62 (18·3%) 268 (32·0%) 101 (29·1%) 221 (26·8%) 97 (27·4%)
Occupation
Low 609 (10·7%) 248 (30·2%) 190 (12·8%) 98 (29·0%) 226 (27·0%) 86 (24·8%) 119 (14·4%) 56 (15·8%)
Intermediate 2530 (44·5%) 425 (51·8%) 619 (41·7%) 154 (45·6%) 401 (47·9%) 151 (43·5%) 356 (43·1%) 141 (39·8%)
High 2548 (44·8) 148 (18·0%) 676 (45·5%) 86 (25·4%) 210 (25·1%) 110 (31·7%) 351 (42·5%) 157 (44·4%)
Cognitive scores
Scores at baseline (2007–09)
Memory (range 0–20) 6·21 (2·21) 4·32 (2·21) 5·51 (2·19) 3·86 (2·22) 4·38 (2·29) 3·98 (2·35) 4·48 (2·25) 4·05 (2·30)
Language (range 0–35) 15·34 (3·46) 11·64 (3·44) 14·56 (3·63) 11·56 (3·97) 11·78 (3·48) 11·63 (3·96) 12·03 (3·51) 11·83 (3·85)
Executive function (range 0–65) 43·92 (10·82) 30·38 (11·34) 41·31 (11·27) 31·05 (11·78) 31·35 (11·74) 32·14 (12·04) 33·06 (11·84) 33·30 (11·86)
Proportion with MMSE <24 (n=45) 0·8% 5·5% 3·0% 13·3% 5·4% 13·0% 5·5% 12·7%
10-year change
Memory −0·32 (1·15) −0·56 (1·39) −1·05 (1·46) −1·23 (1·58) −0·56 (1·39) −1·22 (1·59) −0·62 (1·35) −1·27 (1·50)
Language −0·37 (0·79) −0·49 (1·01) −0·87 (1·02) −0·92 (1·27) −0·51 (1·01) −0·94 (1·26) −0·54 (1·02) −0·97 (1·25)
Executive function −0·27 (0·60) −0·45 (0·69) −0·60 (0·79) −0·78 (0·84) −0·45 (0·69) −0·75 (0·85) −0·48 (0·70) −0·79 (0·85)

Data are mean (SD), n (%), or %. The definitions of cognitive impairment are as follows: (1) age and sex threshold for poor cognitive performance; (2) cognitive decline; (3) age and sex threshold for poor cognitive performance plus cognitive decline; (4) age, sex, and education threshold for poor cognitive performance; (5) age, sex, and education threshold for poor cognitive performance plus cognitive decline; (6) age, sex, and occupation threshold for poor cognitive performance; and (7) age, sex, and occupation threshold for poor cognitive performance plus cognitive decline. MMSE=Mini Mental State Examination.