Fig. 4.

Enforced PGC-1α expression in T cells boosts antitumor immunity. a Schematic representation of the experimental setup for the tumor growth assay. CD45.2 mice were engrafted with 100,000 B16-OVA (s.c.), received 100,000 CD45.1-transduced OT-1 cells (i.v.), followed by OVA/CpG vaccination (s.c.). Either αPD-1 or isotype control was administered (i.p.) on days 9, 12, and 15 post engraftment. Tumor growth was measured from T cell transfer until day 21. b Tumor growth. c Tumor volume at day 21. d Frequencies of transferred cells at the tumor site (% of CD8+). e Absolute number of transferred cells per mm³ of tumor. Data are representative of three independent experiments and are presented as the mean ± SD (6–7 mice per group). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001