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. 2021 Jun 30;11:13562. doi: 10.1038/s41598-021-92112-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of PC and PS in plasma from ALS and PLS patients compared to controls (A) Heat map representation of the most significant fold-changes in the concentration of glycerophosphatidylcholine (PC) species in plasma from ALS and PLS patients compared to controls at the beginning of the study (baseline) and 1 years after (Follow-up). (B) Graph representations of average concentration of specific PC species in ALS and PLS plasma. One-way ANOVA. P values are indicated (C) Heat map representation of the most significant fold-changes in the concentration of glycerophosphatidylserine (PS) species in plasma from ALS and PLS patients compared to controls at the beginning of the study (baseline) and 2 years after (Follow-up). (D) Graph representations of average concentration of specific PS species in ALS and PLS plasma. One-way ANOVA. P values are indicated (n = 40 ALS, 26 PLS samples and 28 controls analyzed in triplicate. *< 0.05; **< 0.01).