. 2021 Jun 30;11:13616. doi: 10.1038/s41598-021-93038-6

Table 2.

AUROC of non-invasive hepatic fibrosis score according to various MRE cutoffs.

	MRE ≥ 2.5 kPa	MRE ≥ 3 kPa	MRE ≥ 3.5 kPa	MRE ≥ 4 kPa	MRE ≥ 4.5 kPa	MRE ≥ 5 kPa
All
FIB-4	0.723 (0.693–0.753)	0.780 (0.750–0.811)	0.805 (0.773–0.837)	0.821 (0.786–0.855)	0.817 (0.779–0.855)	0.851 (0.814–0.888)
APRI	0.742 (0.712–0.771)	0.785 (0.755–0.815)	0.813 (0.782–0.844)	0.816 (0.781–0.850)	0.809 (0.771–0.848)	0.839 (0.801–0.878)
AST/ALT	0.585 (0.550–0.619)	0.628 (0.592–0.664)	0.648 (0.607–0.688)	0.676 (0.633–0.719)	0.689 (0.643–0.736)	0.724 (0.673–0.774
Alcoholic liver disease
FIB-4	0.784 (0.70–0.863)	0.822 (0.759–0.885)	0.799 (0.710–0.848)	0.794 (0.728–0.860)	0.761 (0.689–0.833)	0.773 (0.701–0.845)
APRI	0.726 (0.643–0.809)	0.796 (0.727–0.865)	0.786 (0.716–0.856)	0.788 (0.720–0.857)	0.762 (0.688–0.835)	0.768 (0.692–0.844)
AST/ALT	0.715 (0.623–0.807)	0.722 (0.643–0.800)	0.683 (0.604–0.763)	0.707 (0.629–0.785)	0.689 (0.609–0.769)	0.714 (0.636–0.792)
HBV
FIB-4	0.679 (0.623–0.735)	0.715 (0.652–0.779)	0.764 (0.697–0.831)	0.783 (0.704–0.863)	0.826 (0.744–0.907)	0.899 (0.844–0.953)
APRI	0.748 (0.697–0.799)	0.776 (0.720–0.832)	0.840 (0.785–0.895)	0.855 (0.791–0.920)	0.871 (0.792–0.950)	0.935 (0.900–0.970)
AST/ALT	0.456 (0.395–0.517)	0.497 (0.428–0.565)	0.502 (0.421–0.583)	0.520 (0.429–0.610)	0.534 (0.427–0.641)	0.559 (0.435–0.684)
HCV
FIB-4	0.691 (0.552–0.830)	0.754 (0.617–0.891)	0.764 (0.613–0.916)	0.796 (0.615–0.976)	0.763 (0.569–0.957)	0.789 (0.595–0.983)
APRI	0.655 (0.511–0.799)	0.778 (0.645–0.911)	0.829 (0.692–0.967)	0.839 (0.669–1.000)	0.803 (0.619–0.987)	0.845 (0.676–1.000)
AST/ALT	0.583 (0.433–0.733)	0.618 (0.458–0.777)	0.541 (0.350–0.732)	0.549 (0.327–0.771)	0.527 (0.268–0.767)	0.536 (0.251–0.820)
NAFLD
FIB-4	0.692 (0.621–0.763)	0.756 (0.676–0.837)	0.799 (0.708–0.891)	0.805 (0.690–0.920)	0.720 (0.530–0.910)	0.724 (0.476–0.972)
APRI	0.770 (0.709–0.830)	0.803 (0.736–0.869)	0.814 (0.744–0.885)	0.772 (0.681–0.862)	0.731 (0.597–0.864)	0.816 (0.690–0.942)
AST/ALT	0.541 (0.464–0.619)	0.581 (0.487–0.674)	0.661 (0.553–0.770)	0.694 (0.569–0.819)	0.690 (0.521–0.859)	0.659 (0.395–0.923)
Autoimmune
FIB-4	0.628 (0.546–0.709)	0.702 (0.598–0.806)	0.775 (0.628–0.923)	0.821 (0.693–0.949)	0.821 (0.693–0.949)	0.816 (0.661–0.972)
APRI	0.697 (0.620–0.774)	0.772 (0.688–0.856)	0.790 (0.694–0.886)	0.784 (0.676–0.893)	0.784 (0.676–0.893)	0.844 (0.756–0.932)
AST/ALT	0.529 (0.443–0.615)	0.538 (0.428–0.649)	0.676 (0.498–0.854)	0.827 (0.712–0.942)	0.827 (0.712–0.942)	0.811 (0.652–0.969)

MRE ≥ 2.5 kPa

MRE ≥ 3 kPa

MRE ≥ 3.5 kPa

MRE ≥ 4 kPa

MRE ≥ 4.5 kPa

MRE ≥ 5 kPa

All

FIB-4

0.723

(0.693–0.753)

0.780

(0.750–0.811)

0.805

(0.773–0.837)

0.821

(0.786–0.855)

0.817

(0.779–0.855)

0.851

(0.814–0.888)

APRI

0.742

(0.712–0.771)

0.785

(0.755–0.815)

0.813

(0.782–0.844)

0.816

(0.781–0.850)

0.809

(0.771–0.848)

0.839

(0.801–0.878)

AST/ALT

0.585

(0.550–0.619)

0.628

(0.592–0.664)

0.648

(0.607–0.688)

0.676

(0.633–0.719)

0.689

(0.643–0.736)

0.724

(0.673–0.774

Alcoholic liver disease

FIB-4

0.784

(0.70–0.863)

0.822

(0.759–0.885)

0.799

(0.710–0.848)

0.794

(0.728–0.860)

0.761

(0.689–0.833)

0.773

(0.701–0.845)

APRI

0.726

(0.643–0.809)

0.796

(0.727–0.865)

0.786

(0.716–0.856)

0.788

(0.720–0.857)

0.762

(0.688–0.835)

0.768

(0.692–0.844)

AST/ALT

0.715

(0.623–0.807)

0.722

(0.643–0.800)

0.683

(0.604–0.763)

0.707

(0.629–0.785)

0.689

(0.609–0.769)

0.714

(0.636–0.792)

HBV

FIB-4

0.679

(0.623–0.735)

0.715

(0.652–0.779)

0.764

(0.697–0.831)

0.783

(0.704–0.863)

0.826

(0.744–0.907)

0.899

(0.844–0.953)

APRI

0.748

(0.697–0.799)

0.776

(0.720–0.832)

0.840

(0.785–0.895)

0.855

(0.791–0.920)

0.871

(0.792–0.950)

0.935

(0.900–0.970)

AST/ALT

0.456

(0.395–0.517)

0.497

(0.428–0.565)

0.502

(0.421–0.583)

0.520

(0.429–0.610)

0.534

(0.427–0.641)

0.559

(0.435–0.684)

HCV

FIB-4

0.691

(0.552–0.830)

0.754

(0.617–0.891)

0.764

(0.613–0.916)

0.796

(0.615–0.976)

0.763

(0.569–0.957)

0.789

(0.595–0.983)

APRI

0.655

(0.511–0.799)

0.778

(0.645–0.911)

0.829

(0.692–0.967)

0.839

(0.669–1.000)

0.803

(0.619–0.987)

0.845

(0.676–1.000)

AST/ALT

0.583

(0.433–0.733)

0.618

(0.458–0.777)

0.541

(0.350–0.732)

0.549

(0.327–0.771)

0.527

(0.268–0.767)

0.536

(0.251–0.820)

NAFLD

FIB-4

0.692

(0.621–0.763)

0.756

(0.676–0.837)

0.799

(0.708–0.891)

0.805

(0.690–0.920)

0.720

(0.530–0.910)

0.724

(0.476–0.972)

APRI

0.770

(0.709–0.830)

0.803

(0.736–0.869)

0.814

(0.744–0.885)

0.772

(0.681–0.862)

0.731

(0.597–0.864)

0.816

(0.690–0.942)

AST/ALT

0.541

(0.464–0.619)

0.581

(0.487–0.674)

0.661

(0.553–0.770)

0.694

(0.569–0.819)

0.690

(0.521–0.859)

0.659

(0.395–0.923)

Autoimmune

FIB-4

0.628

(0.546–0.709)

0.702

(0.598–0.806)

0.775

(0.628–0.923)

0.821

(0.693–0.949)

0.821

(0.693–0.949)

0.816

(0.661–0.972)

APRI

0.697

(0.620–0.774)

0.772

(0.688–0.856)

0.790

(0.694–0.886)

0.784

(0.676–0.893)

0.784

(0.676–0.893)

0.844

(0.756–0.932)

AST/ALT

0.529

(0.443–0.615)

0.538

(0.428–0.649)

0.676

(0.498–0.854)

0.827

(0.712–0.942)

0.827

(0.712–0.942)

0.811

(0.652–0.969)

AUROC area under the receiver operating characteristic; Values in parentheses are 95% confidence interval.