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. 2021 Jun 30;11:13558. doi: 10.1038/s41598-021-92922-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representative organogenesis of iPSC-derived islet organoids. At the end of differentiation, the islets were immunofluorescently labeled for (a) C-peptide (CP, red) and glucagon (GCG, green), somatostatin (SST, green) and pancreatic polypeptide (PPY, red). (b) NKX6.1 (green) and CP (red), and MAFA (green) and CP (red). Cells were counterstained with DAPI (grey). Scale bars, 50 μm. Human islets (hIslet) served as a positive control. (c) Semi-quantitative analysis of cellularity of the islets. Image analysis was performed using ImageJ software (n = 7–16 images for each condition). Results are shown as mean ± SD. Different letters indicate significant differences between the groups and p-value represented as *p < 0.05; **p < 0.01; and ***p < 0.001 compared to the control group.