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. 2021 Jun 30;11:13558. doi: 10.1038/s41598-021-92922-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Angiopoietins promote the development of islets with elevated glucose-responsive insulin secretion capacity from differentiation of multiple pluripotent stem cell lines. (a) Parallel glucose-stimulated insulin secretion from islets generated in the absence or presence of Ang2 (n = 6). (b) Insulin stimulation index from consecutive three rounds of low (2 mM)–high (20 mM) glucose challenge measured from iPSC-derived islets by sequential glucose-stimulated insulin secretion analysis. Control (n = 12) and Ang2 (n = 14). (c) Stimulation index of insulin secretion from iPSC-derived islets in the presence of Ang2 at 0 (A0), 4 (A4), 20 (A20), 100 (A100) and 200 ng/ml (A200) (n = 4). Groups with different letters (a or b) represent significant differences. (d-f) Insulin stimulation index of islet organoids generated from iPSC line IMR90 (n = 4) (d), iPSC line DF4 (n = 6) (e), and hESC line H9 (n = 3) (f), respectively. (g) Insulin stimulation index of iPSC-derived islets generated in the presence of Ang1 (n = 4). All the results are shown as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.00, and NS: not significant.