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. 2021 Jun 30;11:13558. doi: 10.1038/s41598-021-92922-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Illustration of Ang2 effect on iPSC islet differentiation and iPSC-derived islet microenvironment. (a) Ang2 supports islet differentiation with the generation of β, α, δ, PP-cells and additionally, promotes the generation of endothelial and pericyte cells. (b-c) iPSC-derived islets under Ang2 cue showed Ca²⁺ influx and regulated activity of CDC42-RAC1 pathway synchronous with glucose level change, leading to F-actin remodeling aided by gelsolin for physiologically functional insulin exocytosis. Created with BioRender.com.