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. 2021 Jun 30;11:13585. doi: 10.1038/s41598-021-93032-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Topology-based pathway analysis showing metabolic pathways affected in lung cancer. The metabolome view shows matched pathways according to the p values from the pathway enrichment analysis and pathway impact values from the pathway topology analysis. The most impacted metabolic pathways are specified by the volume and color of the spheres (yellow, least relevant; red, most relevant) according to their statistical relevance p and impact values.