Table 2.
Comparison of clinical and laboratory variables between the non-critical and critical groups.
| Characteristics | Non-critical (n = 108) |
Critical (n = 32) |
P-value |
|---|---|---|---|
| Age (years) | 57.6 ± 14.3 | 61.9 ± 11.5 | 0.093 |
| Sex | |||
| Male | 61 (56.5) | 24 (75.0) | 0.060 |
| Female | 47 (43.5) | 8 (25.0) | |
| Comorbidities | |||
| COPD | 6 (5.6) | 0 | 0.336 |
| Cardiovascular disease | 14 (13.0) | 2 (6.3) | 0.364 |
| Hypertension | 30 (27.8) | 12 (37.5) | 0.292 |
| Diabetes | 16 (14.8) | 7 (21.9) | 0.344 |
| Symptoms | |||
| Fever | 82 (75.9) | 32 (100) | 0.002 |
| Dry cough | 76 (70.4) | 31 (96.9) | 0.002 |
| Shortness of breath | 46 (42.6) | 31 (96.9) | <0.001 |
| Diarrhea | 6 (5.6) | 3 (9.4) | 0.427 |
| Anorexia | 28 (25.9) | 4 (12.5) | 0.112 |
| Fatigue | 47 (43.5) | 19 (59.4) | 0.115 |
| Laboratory findings | |||
| WBCs (×109/L) | 5.7 ± 2.9 | 8.4 ± 5.6 | 0.010 |
| Neutrophil (×109/L) | 4.2 ± 2.8 | 7.4 ± 5.1 | <0.001 |
| Neutrophil (%) | 66.6 ± 14.7 | 81.2 ± 9.7 | <0.001 |
| Lymphocyte (×109/L) | 1.3 ± 0.6 | 0.9 ± 0.5 | 0.001 |
| Lymphocyte (%) | 24.4 ± 11.1 | 11.7 ± 6.5 | <0.001 |
| Eosinophil (×109/L) | 0.08 ± 0.07 | 0.06 ± 0.09 | 0.061 |
| Eosinophil (%) | 1.5 ± 1.5 | 0.7 ± 1.1 | 0.002 |
| Monocyte (×109/L) | 0.4 ± 0.2 | 0.5 ± 0.3 | 0.183 |
| Monocyte (%) | 7.4 ± 3.1 | 6.1 ± 2.8 | 0.083 |
| Hemoglobin (g/L) | 124.9 ± 20.4 | 121.7 ± 28.8 | 0.694 |
| Platelet (g/L) | 225.5 ± 74.2 | 200.3 ± 79.4 | 0.090 |
| Fibrinogen (g/L) | 3.8 ± 2.2 | 5.0 ± 1.5 | 0.001 |
| d-Dimer (μg/mL) | 0.6 ± 0.9 | 1.6 ± 2.4 | 0.055 |
| hs-CRP (mg/L) | 14.9 ± 18.0 | 46.0 ± 47.5 | <0.001 |
| ALT (U/L) | 33.9 ± 45.4 | 56.6 ± 59.5 | 0.004 |
| AST (U/L) | 26.9 ± 23.8 | 53.2 ± 37.4 | <0.001 |
| TBIL (μmol/L) | 12.5 ± 9.8 | 12.6 ± 5.8 | 0.435 |
| DBIL (μmol/L) | 5.7 ± 20.3 | 4.6 ± 2.5 | 0.054 |
| ALP (U/L) | 63.5 ± 26.2 | 65.7 ± 31.4 | 0.719 |
| Myohemoglobin (μg/L) | 35.2 ± 25.9 | 79.5 ± 62.7 | 0.059 |
| CK (ng/mL) | 66.3 ± 91.7 | 107.4 ± 92.8 | 0.053 |
| LDH (U/L) | 225.7 ± 112.3 | 378.8 ± 147.3 | <0.001 |
| PLT (ng/mL) | 0.3 ± 1.8 | 0.2 ± 0.3 | 0.270 |
| ESR (s) | 35.1 ± 31.9 | 49.4 ± 23.1 | 0.423 |
| NT-proBNP (pg/mL) | 315.5 ± 418.0 | 330.5 ± 491.7 | 0.850 |
| Scr (μmol/L) | 69.2 ± 16.5 | 81.2 ± 22.1 | 0.012 |
| BUN (mmol/L) | 4.6 ± 1.6 | 7.7 ± 4.5 | <0.001 |
| NLR | 4.8 ± 8.7 | 9.3 ± 8.3 | <0.001 |
Data were mean ± SD or number (percentage). P-values were calculated by t-test, Mann–Whitney U-test, χ2-test, or Fisher exact test, as appropriate.
COPD, chronic obstructive pulmonary disease; WBCs, white blood cells; hs-CRP, high-sensitivity C-reactive protein; ALT, alanine transaminase; AST, aspartate aminotransferase; TBIL, total bilirubin; DBIL, direct bilirubin; ALP, alkaline phosphatase; LDH, lactate dehydrogenase; CK, creatine kinase; PLT, procalcitonin; ESR, erythrocyte sedimentation rate; NT-proBNP, N-terminal brain natriuretic peptide precursor; Scr, serum creatinine; BUN, urea nitrogen; NLR, neutrophil-to-lymphocyte ratio. Bold values indicate P < 0.05.