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Role of thrombin in the coagulation system. ICAM, intracellular cell adhesion molecule; PAI, plasminogen activator inhibitor; vWF, von Willebrand factor; IL, interleukin; TAFI, thrombin fibrinolysis activatable inhibitor; TM, thrombomodulin; APC, activated protein C; and F, coagulation factor. Modified from (Davidson, 2013).
