Table 1.
Baseline characteristics of individuals stratified by tertiles of baseline serum hepcidin-25 levels.
| Variable | Total (n = 513) | Serum hepcidin-25 (ng/mL) | P-valuea | ||
|---|---|---|---|---|---|
| ≤24.97(n = 171) | 24.97–64.23 (n = 171) | ≥64.23(n = 171) | |||
| Age (years) | 46 ± 14 | 45 ± 14 | 46 ± 14 | 48 ± 14 | 0.179 |
| Men (n, %) | 309 (60) | 93 (54) | 108 (63) | 108 (63) | 0.160 |
| Body mass index (kg/m2) | 21.6 ± 3.1 | 20.9 ± 2.9 | 22.1 ± 3.1 | 21.8 ± 3.3 | 0.001 |
| Diabetes (n, %) | 122 (24) | 32 (19) | 44 (26) | 46 (27) | 0.157 |
| History of CVD (n, %) | 194 (38) | 68 (40) | 68 (40) | 58 (34) | 0.422 |
| Charlson Comorbidity Index | 3.4 ± 1.7 | 3.2 ± 1.7 | 3.4 ± 1.7 | 3.6 ± 1.7 | 0.091 |
| Hemoglobin (g/L) | 103 ± 21 | 104 ± 22 | 104 ± 20 | 102 ± 21 | 0.588 |
| Albumin (g/L) | 37.30 ± 5.03 | 37.17 ± 4.91 | 37.99 ± 4.80 | 36.74 ± 5.32 | 0.067 |
| Hs-CRP (mg/L) | 1.63 (0.58–4.81) | 1.35 (0.55–4.31) | 1.73 (0.62–4.47) | 1.73 (0.66–7.22) | 0.128 |
| Corrected-calcium (mmol/L) | 2.32 ± 0.18 | 2.32 ± 0.22 | 2.31 ± 0.21 | 2.32 ± 0.18 | 0.898 |
| Phosphorus (mmol/L) | 1.42 ± 0.43 | 1.42 ± 0.49 | 1.41 ± 0.40 | 1.42 ± 0.41 | 0.995 |
| Uric acid (μmol/L) | 427 ± 95 | 418 ± 92 | 431 ± 97 | 432 ± 95 | 0.284 |
| Total cholesterol (mmol/L) | 4.89 ± 1.35 | 4.90 ± 1.49 | 4.87 ± 1.33 | 4.90 ± 1.23 | 0.969 |
| Triglyceride (mmol/L) | 1.42 (0.99–1.98) | 1.35 (0.92–1.87) | 1.38 (1.01–2.04) | 1.50 (1.03–1.90) | 0.241 |
| Total Kt/V | 2.54 ± 0.69 | 2.65 ± 0.69 | 2.42 ± 0.62 | 2.53 ± 0.73 | 0.009 |
| RRF (mL/min/1.73 m2) | 3.55 (2.13–5.33) | 3.51 (2.26–5.66) | 3.79 (2.06–5.53) | 3.55 (2.00–5.09) | 0.565 |
| Iron (μmol/L) | 8.40 (5.20–12.90) | 7.90 (4.00–12.80) | 9.10 (6.20–12.60) | 8.40 (5.43–13.30) | 0.063 |
| TIBC (μmol/L) | 56.10 (46.75–67.35) | 56.30 (49.00–69.20) | 56.80 (46.70–67.60) | 56.30 (46.90–65.40) | 0.409 |
| TSAT (%) | 15 (9–24) | 14 (7–23) | 15 (10–25) | 15 (11–24) | 0.014 |
| Ferritin (ng/mL) | 132.76 (51.32–292.02) | 63.47 (31.59–145.01) | 161.50 (66.75–310.33) | 222.32 (87.74–506.93) | <0.001 |
| ESA users (n, %) | 449 (89) | 150 (91) | 144 (85) | 155 (92) | 0.057 |
| Iron users (n, %) | 369 (72) | 127 (75) | 118 (70) | 124 (73) | 0.544 |
Values expressed as mean ± SD, number (percent), or median (interquartile range).
a
P < 0.05 is considered statistically significant.
CVD, cardiovascular disease; Hs-CRP, high-sensitivity C-reactive protein; Kt/V urea, urea clearance (Kt) normalized to total body water (V); RRF, residual renal function; TIBC, total iron binding capacity; TSAT, transferrin saturation; ESA, erythropoiesis-stimulating agent.