Table 2.
Clinical and laboratory factors associated with serum hepcidin-25 concentration #.
| Variable | Univariate analysis | Multivariable analysis | ||
|---|---|---|---|---|
| Beta (95%CI) | P-value | Beta (95%CI) | P-value | |
| Age (years) | 0.003 (−0.001, 0.007) | 0.104 | – | – |
| Gender (female vs. Male) | −0.108 (−0.209, −0.007) | 0.037 | – | – |
| Body mass index (kg/m2) | 0.028 (0.012, 0.044) | <0.001 | 0.016 (0.0001, 0.031) | 0.044 |
| Charlson Comorbidity Index | 0.029 (0.001, 0.058) | 0.051 | – | – |
| Hemoglobin (g/L) | −0.001 (−0.003, 0.002) | 0.655 | – | – |
| Albumin (g/L) | −0.002 (−0.012, 0.008) | 0.750 | – | – |
| Corrected-Calcium (mmol/L) | −0.034 (−0.279, 0.211) | 0.786 | – | – |
| Phosphorus (mmol/L) | −0.002 (−0.116, 0.113) | 0.977 | – | – |
| Total cholesterol (mmol/L) | −0.029 (−0.065, 0.008) | 0.127 | – | – |
| Triglyceride (mmol/L) | 0.014 (−0.141, 0.287) | 0.502 | – | – |
| Uric acid (μmol/L) | 0.001 (0.0001, 0.001) | 0.017 | – | – |
| Hs-CRP (mg/L) | 0.116 (0.028, 0.203) | 0.009 | – | – |
| Iron (μmol/L) | 0.285 (0.125, 0.445) | <0.001 | – | – |
| TIBC (μmol/L) | 0.285 (0.125, 0.445) | <0.001 | – | – |
| Ferritin (ng/mL) | 0.448 (0.361, 0.535) | <0.001 | 0.435 (0.342, 0.527) | <0.001 |
| TSAT (%) | 0.345 (0.185, 0.505) | <0.001 | – | – |
| Total Kt/V | −0.098 (−0.172, −0.025) | 0.009 | – | – |
| RRF (mL/min/1.73 m2) | −0.064 (−0.208, 0.081) | 0.387 | – | – |
#
Natural log-transformed serum hepcidin-25 was used as the dependent variable in univariable and a multivariable linear regression models to identify independent factors. Triglyceride, hs-CRP, iron, TIBC, ferritin, TSAT and RRF were also log-transformed. 95% CI, 95% confidence interval; Hs-CRP, high-sensitivity C-reactive protein; TIBC, total iron binding capacity; TSAT, transferrin saturation; Kt/V urea, urea clearance (Kt) normalized to total body water (V); RRF, residual renal function. Bold indicates significance at P < 0.05.