Table 3.
Associations of tertiles of serum hepcidin-25 with all-cause, cardiovascular and infection-related mortality.
| No. of deaths (%) | Model 1a | Model 2b | Model 3c | ||||
|---|---|---|---|---|---|---|---|
| All-cause mortality | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Tertile 1 | 34 (19.9) | 1.20 (0.74–1.93) | 0.463 | 1.17 (0.72–1.91) | 0.526 | 1.31 (0.77–2.24) | 0.315 |
| Tertile 2 | 33 (19.3) | 1.0 | 1.0 | 1.0 | |||
| Tertile 3 | 55 (32.2) | 1.71 (1.11–2.63) | 0.015 | 1.83 (1.18–2.83) | 0.007 | 1.85 (1.14–3.00) | 0.013 |
| Cardiovascular mortality | SHR (95% CI) | P-value | SHR (95% CI) | P-value | SHR (95% CI) | P-value | |
| Tertile 1 | 19 (11.1) | 1.18 (0.62–2.25) | 0.608 | 1.12 (0.59–2.12) | 0.738 | 1.46 (0.71–2.98) | 0.304 |
| Tertile 2 | 18 (10.5) | 1.0 | 1.0 | 1.0 | |||
| Tertile 3 | 24 (14.0) | 1.32 (0.72–2.43) | 0.369 | 1.24 (0.68–2.28) | 0.482 | 1.33 (0.64–2.78) | 0.443 |
| Infection-related mortality | SHR (95% CI) | P-value | SHR (95% CI) | P-value | SHR (95% CI) | P-value | |
| Tertile 1 | 7 (4.1) | 1.11 (0.39–3.16) | 0.847 | 1.24 (0.42–3.60) | 0.699 | 0.80 (0.23–2.84) | 0.735 |
| Tertile 2 | 7 (4.1) | 1.0 | 1.0 | 1.0 | |||
| Tertile 3 | 18 (10.5) | 2.42 (1.02–5.73) | 0.045 | 2.61 (1.07–6.36) | 0.034 | 2.61 (1.01–6.76) | 0.049 |
HR, hazard ratio; SHR, Subdistribution hazard ratio; 95% CI, 95% confidence interval. Bold indicates significance at P < 0.05.
a
Unadjusted model.
b
Adjusted for age, gender, body mass index.
c
Adjusted for model 2 covariates and uric acid, corrected calcium, phosphorus, albumin, comorbidity score, hemoglobin, residual renal function, total Kt/V, high-sensitivity C-reactive protein level, serum ferritin and treatment of erythropoiesis-stimulating agents (ESAs) and/or iron.