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. 2021 Jun 17;9:687912. doi: 10.3389/fcell.2021.687912

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Copyright © 2021 Li, Zhang, Li, Guo, Li, Zhang, Li and Mi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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sEV-miRNAs loaded by hnRNPA1 facilitate tumor proliferation and migration. (A) Bubble chart showing the 19 downregulated sEV-miRNA-associated KEGG pathways. DIANA TOOLS-mirPath v.3 was used, and 20 of the most associated pathways are shown. (B) Confocal microscope images showing CD63-dsRed-labeled sEVs uptaken by A549 cells (sEVs, red; and nucleus, blue). (C) Cell viability of A549 (*p < 0.05, error bars represent SEM). (D) Wound-healing assay of A549 cells treated with different sEVs. NC, A549 cells without exogenous sEVs; shCTR, A549 cells adding sEVs derived from shCTR cells; shhnRNPA1, A549 cells adding sEVs derived from shhnRNPA1 cells. sEV-miRNA, microRNA in small extracellular vesicle; hnRNPA1, heterogeneous nuclear ribonucleoprotein A1; KEGG, Kyoto Encyclopedia of Genes and Genomes.