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. 2021 Jun 17;12:693725. doi: 10.3389/fmicb.2021.693725

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Copyright © 2021 Zhao, Wang, Shukla, Kumar, Weingarth, Breukink and Kuipers.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The structures of brevibacillins and the predicted biosynthetic gene cluster. (A) The non-ribosomal peptide synthetase genes harbored by the Brevibacillus laterosporus DSM 25 genome. (B) The catalytic domains encoded by the gene cluster and the substrates incorporated by the respective modules. Domains: A, adenylation; KR, ketoreductase; T, thiolation; C, condensation; E, epimerization; TD, terminal reductase; TE, thioesterase. (C) Structures of brevibacillins. The red rectangles indicate the more hydrophobic amino acid residues of brevibacillin V, brevibacillin, and brevibacillin I relative to brevibacillin 2V.