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. 2021 Jun 17;8:697773. doi: 10.3389/fmolb.2021.697773

FIGURE 2.

FIGURE 2

LINC00174 knockdown inhibits OS cell proliferation, migration and invasion. (A) The transfection efficacy of sh-LINC00174 or sh-NC in U2OS and MG63 cells was examined by RT-qPCR analysis. Significance was analyzed by Student’s t-test. (B) CCK-8 assay was used to evaluate the viability of U2OS and MG63 cells transfected with sh-LINC00174 and sh-NC. Significance was analyzed by Student’s t-test. (C,D) Colony formation assay was used to measure the proliferation of U2OS and MG63 cells transfected with sh-LINC00174 and sh-NC. Significance was analyzed by Student’s t-test. (E) Wound healing assay was used to determine the migration of OS cells transfected with sh-LINC00174 and sh-NC. Significance was analyzed by Student’s t-test. (F,G) Transwell assays were used to detect the migration and invasion of OS cells transfected with sh-LINC00174 and sh-NC. Significance was analyzed by Student’s t-test. *p < 0.05.