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. 2021 Jun 17;8:697773. doi: 10.3389/fmolb.2021.697773

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Copyright © 2021 Zheng, Li, Zheng, Fang, Xu and Zhong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiR-378a-3p upregulation suppresses the TGF-β/SMAD pathway. (A) The mRNA expression levels of TGF-β1, SMAD2 and SMAD3 in OS cells transfected with NC mimics or miR-378a-3p mimics were determined by RT-qPCR analysis. Significance was analyzed by Student’s t-test. (B,C) Western blot measured the protein levels of TGF-β1, SMAD2, SMAD2 (phospho S255), SMAD3, and SMAD3 (phospho T179) in OS cells transfected with sh-LINC00174 or sh-NC group. Significance was analyzed by Student’s t-test. *p < 0.05.