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Pharmacologic inhibition of NEDDylation pathway blocks OxLDL-induced HDAC6 activity. (A) HAECs pretreated with MLN4924 (1 μM) for 2 h were exposed to either phosphate-buffered saline (control) or increasing concentrations of OxLDL (50, 100 μg/mL) for 6 h. Cell lysates were immunoblotted (IB) with acetylated α-tubulin and total α-tubulin antibodies. (B) Densitometric analysis of acetylated α-tubulin. ∗p < 0.05 vs. control group; #p < 0.05 vs. OxLDL group; n = 3.
