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. 2020 Nov 24;11(6):1446–1468. doi: 10.1016/j.apsb.2020.11.015

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Fig. 2 — PPIs between Hsp90 middle domain and Aha1 (A) Co-crystal structure of Hsp90 (green) and Aha1 (red). (B) Hydrophobic interface between Hsp90 and Aha1, mediated by hydrogen bonding between Q314 of Hsp90 and the backbone of I64 and S65 on Aha1. (C) Hydrogen bonding and ionic interactions between Hsp90 lysines and Aha1 aspartic/glutamic acids. (D) Ion-pair interactions between K469, K514, and E515 on Hsp90 and D110, Q122, and R128 on Aha1 (PDB: 1USU ⁴⁶).