Table 1.
A listing of Hsp90 clients implicated in Hanahan and Weinberg's hallmarks of cancer.
| Hallmarks of cancer | Implicated Hsp90 client proteins | Ref. |
|---|---|---|
| Self-production of growth signals | Raf-1, Akt, Her-2, Mek, Bcr-Abl, Xpo1 | 27,28 |
| Insensitivity to anti-growth signals | Plk, Wee 1, Myt1, Cdk4, Cdk6 | 27 |
| Evasion of apoptosis | Akt, p53, c-Met, Apaf-1, survivin, WT1 | 27, 28, 29 |
| Angiogenesis | Fak, Akt, HIF-1α, VEGFR, Flt-3, Tp73, Tbk1 | 27, 28, 29 |
| Replicative senescence | Telomerase, FoxM1, Ntrk1, Ntrk2, Ntrk3 | 27, 28, 29 |
| Tissue invasion/metastasis | c-Met, HIF-1α, Prmt5, Ikbka, Nuak2, MMP2 | 27, 28, 29 |
| Dysregulation of cellular energetics | Arnt, Arrb1, Arrb2, Hmga1 | 27,28 |
| Evasion of the immune response | Irak3 | 27,28 |
| Genome instability and mutations | Mafg, Nek8, Nek9, Nek11 | 27,28 |
| Tumor-promoting inflammation | IkbkA, IkbkB, IkbkG, IL-6, IL-8 | 27,28 |