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The t1/2 of compound a2 and verapamil in liver microsomes of different species.
| Species |
t1/2 (min) |
CL (μL/min/mg) |
||
|---|---|---|---|---|
| a2 | Verapamil | a2 | Verapamil | |
| Human | 34.9 | 26.9 | 99.4 | 128.8 |
| Rat | 31.2 | 13.7 | 111.2 | 252.7 |
| Mouse | 23.7 | 10 | 146.3 | 347.3 |
| Dog | 32.2 | 17.8 | 107.7 | 194.8 |
| Monkey | 23.5 | 4.8 | 147.7 | 725.7 |
