Table 2.

Generalized Estimating Equation Analyses of Associations Between Frailty and 4-Year Mortality Over Time for Participants Aged 64–84 Years in the Longitudinal Aging Study Amsterdam, the Netherlands, 1995–2016^a

Variables	Total			Men			Women
	OR	95% CI	P	OR	95% CI	P	OR	95% CI	P
Model 1
Frailty	2.79	2.39, 3.26	<0.001	2.98	2.42, 3.68	<0.001	2.53	2.02, 3.18	<0.001
Model 2
Frailty	2.88	2.47, 3.37	<0.001	3.13	2.54, 3.87	<0.001	2.57	2.05, 3.24	<0.001
Time, years	0.97	0.95, 0.98	<0.001	0.96	0.94, 0.97	<0.001	0.98	0.96, 1.00	<0.05
Model 3
Frailty	2.56	2.02, 3.23	<0.001	2.88	2.08, 4.01	<0.001	2.34	1.64, 3.33	<0.001
Time, years	0.96	0.94, 0.97	<0.001	0.95	0.93, 0.97	<0.001	0.97	0.94, 1.00	<0.05
Frailty × Time	1.02	0.99, 1.05	0.16	1.01	0.98, 1.05	0.51	1.01	0.98, 1.05	0.47

Abbreviations: CI, confidence interval; OR, odds ratio.

^a The analyses include 7,742 observations of 2,874 respondents. All models were adjusted for age and sex; sex adjustment only in the analysis of the total population. Frailty was defined as having a frailty index of ≥0.25.