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. 2021 Apr 20;151(7):1802–1816. doi: 10.1093/jn/nxab087

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© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited

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Twenty-four hour kinetics of plasma total curcuminoids after consumption of a single dose of the turmeric formulations STE, TEP, PHYT, NOV, and TPG by healthy human participants. (A) Concentrations of total curcuminoids; and (B) dose-normalized concentrations of total curcuminoids determined using UHPLC-tandem MS. Observed means ± SD on the ITT population, n = 30 for each formulation. Total curcuminoids = curcumin + curcumin sulfate + curcumin glucuronide + DMC + DMC sulfate + DMC glucuronide + BDMC + BDMC glucuronide + BDMC sulfate + THC + THC sulfate + THC glucuronide + HHC + HHC glucuronide + HHC sulfate. BDMC, bisdemethoxycurcumin; DMC, desmethoxycurcumin; HHC, hexahydrocurcumin; ITT, intent-to-treat; NOV, liquid micellar formulation; PHYT, phytosome formulation; STE, standard turmeric extract; TEP, piperine-curcuminoids combination; THC, tetrahydrocurcumin; TPG, Turmipure Gold formulation; UHPLC, ultra-high-pressure liquid chromatography.