TABLE 8.

Calculation of the quantity of curcuminoids (and finished products) to be ingested for each formula to reach the same AUC 0–24h as observed after consumption of 300 mg of TPG by healthy human participants (6520 ng·h/mL)¹

	STE	TEP	PHYT	NOV	TPG
Dose-normalized AUC 0–24h of total curcuminoids, ng·h/mL/mg	3.7	3.2	13.0	136	72.9
Expected AUC 0–24h of total curcuminoids, ng·h/mL	6520
Quantity of curcuminoids (finished product) to be consumed,2 mg	1760 (1920)	2040 (2260)	502 (2870)3	48 (763)4	90 (300)

¹NOV, liquid micellar formulation; PHYT, phytosome formulation; STE, standard turmeric extract; TEP, piperine-curcuminoids combination; TPG, Turmipure Gold formulation.

²The calculation is done using the corresponding dose normalized AUC 0–24h obtained for each product to reach 6520 ng·h/mL, and the quantity 0of product is therefore calculated based on the curcuminoids content quantified for each product (from Table 1).

³Here we considered phytosome formulation (PHYT) dose-normalized AUC to be the same as that obtained at 1000 mg in our study despite the dose obtained from calculation being higher. However, because relative bioavailability is dose dependent (see Discussion), the dose equivalence may be inferior to 2870 mg because relative bioavailability would be higher.

⁴Here we considered micellar formulation (NOV) dose-normalized AUC to be the same as that obtained at 1000 mg in our study despite the dose obtained from calculation being lower. However, because relative bioavailability is dose dependent (see Discussion), the dose equivalence may be superior to 763 mg because relative bioavailability would be lower.