Figure 3.

The mean ± SEM lumen-to-blood intestinal effective permeability (P_eff) ratio of (a) enalaprilat and (b) hexarelin, and (c) the blood-to-lumen ⁵¹Cr-EDTA clearance (CL_Cr-EDTA) ratio, after the intestinal perfusions of a control solution for 60 min, followed by a 75-min perfusion of any of five test solutions with constituents reported to increase paracellular permeability. There were three isotonic (290 mOsm) test solutions containing EDTA at 1 and 5 mg/mL, and chitosan at 5 mg/mL, and two hypotonic test solutions (100 mOsm) with or without lidocaine (L). All perfusates were at pH 7.4, except chitosan (pH 6.5). A ∗ represents a significant increase in P_eff or CL_Cr-EDTA ratio.