Table 1.

Physicochemical properties of the two study drugs: enalaprilat²² and hexarelin²³.

Substance (BCS class)	MM (Da)	pKa	PSA	HBA/HBD	LogP	LogD7.4	LogD6.5
Enalaprilat (III)	348	3.17b/7.84a	102.1	6/3	−0.13	−1.0	−1.0
Hexarelin (III)	887	–	300	9/11	0.73	−2.26	−3.40

HBA/HBD, hydrogen bond acceptor/donor; LogD_7.4/6.5, n-octanol−water partition coefficient at pH 7.4/6.5; LogP, n-octanol−water coefficient; MM, molar mass; pKa, dissociation constant; PSA, polar surface area.

^aAcid.

^bBase.