Table 3.

The absolute effective permeability of enalaprilat and hexarelin in the control period (buffer at pH 7.4 and 6.5), and the five different test periods: three isotonic (290 mOsm) test solutions containing EDTA at 1 and 5 mg/mL, and chitosan at 5 mg/mL, and two hypotonic test solutions (100 mOsm) with or without lidocaine (L).

Perfusate composition	Effective permeability ( × 10−4 cm/s)a
	Enalaprilat	Hexarelin
Control 1 pH 6.5	0.009 ± 0.003	0.018 ± 0.0.6
Control 2 pH 7.4	0.010 ± 0.005	0.016 ± 0.01
EDTA 1 mg/mL	0.014 ± 0.003	0.017 ± 0.008
EDTA 5 mg/mL	0.069 ± 0.036	0.068 ± 0.055
Chitosan 5 mg/mL	0.057 ± 0.024	0.082 ± 0.064
100 mOsm	0.010 ± 0.005	0.032 ± 0.017
100 mOsm+L	0.017 ± 0.009	0.029 ± 0.015

^aData are mean ± SD. All test perfusates were at pH 7.4, except chitosan (pH 6.5). n = 6 for all groups except Control at pH 7.4 where n = 23.