Skip to main content
. 2021 Feb 10;11(6):1578–1591. doi: 10.1016/j.apsb.2021.02.005

Figure 1.

Figure 1

The expression of LIX1L positively correlates with unfavorable prognosis of human HCC. (A) The expression of LIX1L in HCC (n = 369) and non-tumour tissues (n = 160) from GEPIA database. Based on the selected TCGA tumors and TCGA normal + GTEx normal datasets performed difference analysis (one-way ANOVA). (B) Kaplan–Meier overall survival curve of HCC patients, using the TCGA datasets in the GEPIA database. High and low expression of LIX1L were stratified by the median. (C) Kaplan–Meier survival analysis of patients with HCC using KMplot (http://kmplot.com). (D) Relative expression of LIX1L from 30 HCC tumor and adjacent non-tumor tissues measured by qRT-PCR. (E) LIX1L expression of tumor and adjacent non-tumor tissues detected by immunofluorescence (left) with quantized analyses of paired clinical HCC samples (n = 80). Scale bar = 50 μm. (F) Left, the schematic diagram of DEN + CCl4 induced HCC model (top) and liver images (bottom). Right, tumor numbers (n = 6). (G) Representative hematoxylin and eosin (H&E) staining showed proliferation of tumor cells. Scale bar = 2.5 mm (left), 100 μm (right). ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001.