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. 2021 Feb 10;11(6):1578–1591. doi: 10.1016/j.apsb.2021.02.005

Figure 6.

Figure 6

LIX1L regulates glucose metabolism of HCC via FBP1. Gene (A) and protein (B) detection of FBP1 expression in HCCLM3 and HepG2 cells transfected with LIX1L siRNA or LIX1L plasmid. (C) The correlation between LIX1L and FBP1 in HCC patients from GEO database (GSE45436) was analyzed. Endogenous FBP1 expression in tissue samples from HCC mice (D) and xenograft models (E) were measured by Western blot analysis or immunohistochemical staining. Scale bar = 100 μm. The migration and invasion abilities (F), glucose and lactate levels (G) were measured in LIX1L stable overexpression HepG2 cells transfected with FBP1 plasmid or LIX1L stable knockdown HCCLM3 cells transfected with FBP1 siRNAs. Scale bar = 100 μm. ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001.