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. 2021 Aug;11(8):3518–3534. doi: 10.21037/qims-20-443

Figure 7.

Figure 7

Primary mCAFs were isolated from 4T1-GFP xenograft mice and verified by expression of α-SMA with immunofluorescence (A,B) (A,B: magnification: 400×). The comparison of protein expression of DDR2 in breast tumor CAFs by knocking out FAP via CRISPR/Cas9 technology (C). Cell proliferation was inhibited in breast tumor CAFs with FAP knockout via CRISPR/Cas9 (D). **, P<0.05; ***, P<0.01. CAFs, carcinoma-associated fibroblasts; mCAF, mouse CAF; α-SMA, alpha-smooth muscle actin; DDR2, discoidin domain receptor 2; FAP, fibroblast activation protein.