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Deletion of DDR2 by CRISPR/Cas9 technology in breast tumor CAFs results in decreased tumor stiffness measured by UE (A,B,C) and inhibition of tumor growth (D,E). Representative B-mode (left) and UE (right) images in split-screen mode (A,B). ***, P<0.01. DDR2, discoidin domain receptor 2; CAFs, carcinoma-associated fibroblasts; UE, ultrasound elastography; US, ultrasound.
